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riehlism
Junior Member
US
185 Posts |
 Posted - 07/27/2010 : 3:44:42 PM
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We know there are a number of theories regarding PE. There are thrombophilias, and then there's poor implantation.
Does anyone have information about having a recent miscarriage (or an incomplete miscarriage) and then getting pregnant that resulted in PE. If a woman had a miscarriage and the uterus wasn't able to clean out that old endometrial lining and then got pregnant, it would make sense that poor implantation may take place.
I've seen on the Forums that some women may have had a history of miscarriages.
I know in my case I had a chemical pregnancy (at least I think it was). I had a period at the middle of Nov of 2009. Then the day before thanksgiving I had horrible abdominal pain and started bleeding a lot on Thanksgiving day, when I had a period just two weeks prior. The Thanksgiving period was unusually heavy.
A month later I was pregnant with my son, who died soon after he was born. I had PE and HELLP and had to deliver at 24+6.
Anyone have information on this possible connection? |
Jasmin (28): PCOS, MTHFR mutation. Severe Early Onset PE with HELLP at 24+6; DH Frank (28)
Baby Blue stopped in to say hello and goodbye 6/3/10 |
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alexa5
Advanced Member
US
556 Posts |
Posted - 07/27/2010 : 4:09:49 PM
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I guess the other thing to consider is that many women that have miscarriages do have to have a d&c or d&e, which does then clean all of that out (I think). I realize that some women miscarry on their own, but just wanted to throw that out there. I was one that needed a d&e. I did get pre-e in the next pregnancy, but my understanding is that there is not a connection unless someone has underlying conditions that might impact them.
I feel like this topic has come up before, so I will do a quick search to see if there is something more scientific than my answer :-) |
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amypete
Junior Member
126 Posts |
Posted - 07/27/2010 : 6:58:20 PM
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| In my 3rd pregnancy I had a fetal demise at 19 weeks that resulted in a D&E. Up to that point I hadn't had any signs of pre-e. They thought it was a DNA problem and tested for those things, which came back fine. It was too late at that point to do other tests. My 4th pregnancy was over by 9 weeks and I knew it wasn't going to last because I didn't feel pregnant. Then I got mild pre-e in my 5th pregnancy. That's my 2 cents! |
DD Jillian 2/01 severe pre-e
DS Hayden 3/03 severe pre-e
2 losses
DD Kara Jane 8/07 mild pre-e
Due 8/24/10 with a girl! Mild pre-e dx as of 7/10 |
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Caryn
Ask the Experienced Moderator
USA
8903 Posts |
Posted - 07/27/2010 : 7:39:52 PM
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A history of miscarriage is a risk factor for PE, because one big reason miscarriages happen is that the implantation doesn't take. They all get lumped together under "failed" or "defective" because the question of *why* it is that a given pregnancy has failed is so difficult to investigate. But in some pregnancies it's embryonic demise for reasons having to do with development of the embryonic portion of the pregnancy and in some it's development of the placental portion (and in some both, of course.)
I know there's more discussion of this in the New Yorker article and some of the abstracts posted to the News forum. Generally they'll talk about it on a continuum, with very shallow implantations leading to miscarriage and merely shallow implantations leading to PE, but this is a sloppy way to talk about it, I think; really there are a bunch of things in play and implantation is a huge component but not the only factor. |
Science is getting us closer to finding a cause, and even a cure. The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies? Lectures from researchers? A chance to participate in research?
Caryn, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE |
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Caryn
Ask the Experienced Moderator
USA
8903 Posts |
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jules2
Junior Member
UK
409 Posts |
Posted - 07/28/2010 : 06:18:07 AM
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I think Caryn has explained it well. I also have a history of mmc and mc; one of each after my PE stillbirth and one mc before. Its hard to stay positive with so many pregnancy losses, but I've always got pregnant very easily within 1-2 months so the experts have encouraged me to just keep trying.
I expect it my case the miscarriages hace been due to poor implantation (but I'm also of advanced maternal age, anther major mc risk factor of course).. |
Mother to Alice, stillborn on 05/09/09 at 26+1 weeks
Missed miscarriage at 8 weeks, Nov 2009 & mc at 5 weeks Feb 2010
Pregnancy no. 4 due 12/29/10 |
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jenmatt1
Junior Member
US
341 Posts |
Posted - 07/28/2010 : 06:27:56 AM
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| jules- we must live parallel lives- same here for miscarriage. I always gets pregnant easily within a few months of trying but had miscarriages before my daughter was born- then one in 2nd trimester after she was born and another in Jan 2010. Now I am again pregnant and due Jan 10th. I have no underlying issues that they can find at this point. So I think it is connected somehow- I just don't know how. |
Jennifer
Mom to Olivia, born 04/04/2008 at 34 weeks due to HELLP
Expecting Baby 2-It's a boy- Declan James Due Date January 10th, 2011
http://pregnantjennysmartpants.blogspot.com |
Edited by - jenmatt1 on 07/28/2010 06:28:37 AM |
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honeykovu
Starting Member
US
2 Posts |
Posted - 07/31/2010 : 04:30:54 AM
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It's an interesting theory.
I had a missed m/c 2 months before my pre-eclampsia pregnancy. I had a d&c and then took the pills since I still had retained tissue after the d&c.
I also lost my daughter's twin a month at 21 weeks (a month before I was diagnosised with pre-eclampsia). I wonder if that played a role, or also the SCH I had at 8 weeks. The doctor's believe my daughter's twin had a chromosomal problem since it suffered growth restriction very early in the pregnancy, but I believe it was a placenta problem instead since besides the baby not growing past 15 weeks in size it was fine organ wise and everything was normal until my 18 week anatomy scan (I had 7 perfect u/s before this - the last one being 8 days before).
I do wonder if I have a clotting problem since even the first baby I lost was chromosomally normal (though the doctors won't admit to it since it came back female). Plus since we have to go through ivf to conceive I don't want to get pregnant a third time and experience another loss or pre-eclampsia again if it can be prevented. |
dd born 3/5/10 at 31w0d due to severe pre-eclampsia. |
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Caryn
Ask the Experienced Moderator
USA
8903 Posts |
Posted - 07/31/2010 : 9:17:15 PM
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Here's an abstract from a good journal. It says After conception, regulatory T cells, interacting with indoleamine 2,3-dioxygenase, together with decidual NK cell recognition of fetal HLA-C on extravillous trophoblast may facilitate placental growth by immunoregulation. Complete failure of this mechanism would cause miscarriage, while partial failure would cause poor placentation and dysfunctional uteroplacental perfusion. The first pregnancy preponderance and partner specificity of pre-eclampsia can be explained by this model.
In English, that pretty much means that some miscarriages happen when your immune system can't talk to the cells that will go on to form the placenta. And when they can have a conversation, kind of, with a substantial language barrier, you get preeclampsia. In a first pregnancy, they often can't communicate very effectively, so both miscarriages and preeclampsia are more common in first pregnancies. Sometimes two people just cannot learn one another's languages, and all the pregnancies have these issues.
I suppose this means you get a normal placenta from two English majors. (Except DH and I both have undergrads in English. Oh, well.) |
Science is getting us closer to finding a cause, and even a cure. The articles you don't want to miss:
The Preeclampsia Puzzle (New Yorker) and Silent Struggle: A New Theory of Pregnancy (New York Times)
Looking for recent articles and studies? Lectures from researchers? A chance to participate in research?
Caryn, who is not a doctor and who talks about science stuff *way* too much
DS Oscar born by emergent C-section at 34 weeks for fetal indicators, due to severe PE |
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Recent and/or Incomplete Miscarriage and PE risk?
